CONDUCT OF PREGNANCY

We are a team of experienced specialists in gynecology and obstetrics, ready to accompany you at every stage of your pregnancy journey. At Mediss Medical Clinic, we combine the highest quality medical care with an individual approach, taking care of your health and the health of your child.

Our team of gynecologists will follow the development of your pregnancy from the beginning until the moment of birth. Thanks to our commitment and regular check-ups, we will provide you with comprehensive care, monitoring both your health and your child’s development.

We offer a wide range of prenatal tests that will help you better understand your baby’s health before birth. Our advanced diagnostic technologies will provide you with accurate and reliable test results, giving you peace of mind and confidence during your pregnancy.

We provide patients with full medical care, both obstetrics and doctors of other specialties, such as endocrinologists and diabetologists. We also offer advice from a urogynecological physiotherapist.

We ensure the availability of necessary examinations and tests performed in one place.

We manage patients with physiological and high-risk pregnancies, based on the latest recommendations of scientific societies.

Scope of services provided:

• preparation for pregnancy
• managing physiological and high-risk pregnancies, including
• multiple pregnancies
• prenatal ultrasound diagnostics, including 3D/4D ultrasound
• PAPP-A test with trisomy risk assessment
• fetal echocardiography (ECHO of the fetal heart)
• extension of the PAPP-A test to include the PlGF test (assessment of the risk of preeclampsia)
• SANCO RhD test – non-invasive assessment of the RhD factor in the fetus (assessment of the risk of serological conflict)
• Doppler flow examination in the fetus
• Breast ultrasound in pregnant women
• insertion of obstetric pessaries in cases of shortening of the cervix
• colposcopy of the cervix during pregnancy
• aesthetic gynecology (e.g. removal of condylomas, vaginal revitalization after childbirth)
• urogynecological and perinatal physiotherapy
• postpartum care.

PRENATAL DIAGNOSIS:

PRENATAL TEST PANORAMA

The Panorama test is a non-invasive, new generation prenatal screening test performed based on free fetal cfDNA present in the mother’s blood from the 10th week of pregnancy.

The Panorama Prenatal Test detects diseases:

• Down syndrome
• Edwards syndrome
• Patau syndrome

and certain sex chromosome abnormalities:

• Turner syndrome,
• Jasoba team,
• triple X syndrome,
• Klinefelter syndrome,
• triploidy.

Triploidy is a chromosomal abnormality that very often leads to fetal death and is associated with serious congenital defects and preeclampsia.

Principle of performing the PANORAMA test:

Free fetal DNA (cfDNA) of the fetus penetrates the placental barrier into the peripheral blood of the pregnant woman. After the 10th week, 10 ml of the pregnant woman’s blood is collected for testing, from which fetal cfDNA is isolated. The fetal cfDNA is multiplied and sequenced, i.e. the order of nucleotide pairs is read. Trisomy risk assessment – comparison of sequences unique to fetal chromosomes with a set of reference chromosomes.

Why is it worth choosing the PANORAMA test:

• has a certificate of compliance for all reagents and procedures
• sensitivity and specificity exceed 99.9% after the 10th week and remain at the same level throughout pregnancy
• false positive rate: <1%
• non-invasive test, completely safe

Who is the PANORAMA test intended for?

The test is intended for all women:

• at all ages and from every risk group
• in a singleton pregnancy
• after natural or in vitro fertilization
• after the 10th week of pregnancy

Contraindications to performing the test:

• patients with diagnosed mosaicism
• in a twin pregnancy in which one embryo died
• after previous stem cell therapy
• patients in whom the time from the last blood transfusion to the start of pregnancy was less than half a year
• during severe infection

VERACITY PRENATAL TEST

The Veracity prenatal test is one of the newer, advanced screening tests used to assess the risk of genetic defects in the fetus. It is a non-invasive test, which means it is safe for both mother and baby because it only involves taking a sample of the mother’s blood. The test can be performed from the 10th week of pregnancy.

Technology: The Veracity test is based on technology that analyzes free fetal DNA (cffDNA) present in the mother’s blood. This allows for the assessment of the risk of various chromosomal aberrations in the fetus.

What diseases can VERACITY detect?

AUTOSOMAL ANEUPLOIDIES

• Down syndrome (trisomy 21)
• Edwards syndrome (trisomy 18)
• Patau syndrome (trisomy 13)

ANEUPLOIDIES OF SEX CHROMOSOMES

• Turner syndrome (X chromosome monosomy)
• XXX syndrome (trisomy of the X chromosome)
• Klinefelter syndrome (XXY)
• Jacobs syndrome (XYY)
• XXYY team

The Veracity test has high sensitivity and specificity, which means it has a low rate of false-positive and false-negative results. Accuracy depends on the type of aberration being tested, but is generally over 99% for the most common trisomies. Veracity test results are typically available within 5-7 business days after the sample arrives at the laboratory.

The Veracity test is valued for its precision and safety, making it a popular choice among expectant parents who want accurate information about their baby’s health before birth.

VERAGENE PRENATAL TEST

The Veragene Prenatal Test is an advanced, non-invasive prenatal test (NIPT) that combines traditional fetal genetic testing with parental genetic analysis. Its aim is to detect both chromosomal aberrations and monogenic diseases, i.e. those resulting from mutations in a single gene. The Veragene test uses next-generation sequencing (NGS) technology to analyze fetal cffDNA present in the mother’s blood and parental DNA. This allows the identification of a wide range of potential genetic disorders.

Scope of research:

• Down syndrome
• Edwards syndrome
• Patau syndrome
• and other chromosomal aberrations, including monosomies and duplications.

The Veragene test analyzes the risk of numerous monogenic diseases, such as cystic fibrosis, spinal muscular atrophy (SMA), thalassemia,
X-fragile band. The test covers over 100 different monogenic diseases.

The test can be performed from the 10th week of pregnancy. The procedure involves taking a blood sample from the mother and saliva samples from both parents.
Accuracy: Veragene is characterized by high sensitivity and specificity for detected disorders. By analyzing the parents’ DNA, the test increases the accuracy in assessing the risk of monogenic diseases, which allows for more precise predictions and minimization of false positive results.

Veragene test results are typically available within 10-14 business days after samples arrive at the laboratory.

The Veragene test offers a comprehensive genetic screening, making it one of the most advanced prenatal tests available, enabling parents-to-be to make informed decisions about their baby’s health.

NIFTY PRENATAL TEST

The test can be performed from the 10th week of pregnancy,  it is completely safe for the mother and the baby because it only requires taking the mother’s blood, which eliminates the risk of miscarriage associated with more invasive diagnostic methods. The NIFTY (Non-Invasive Fetal TrisomY) test is one of the most famous and widely used non-invasive prenatal tests (NIPT), which is used to detect the risk of certain genetic defects in the fetus.

The NIFTY test uses the analysis of free fetal DNA (cffDNA) circulating in the mother’s blood. The test is based on next-generation sequencing (NGS) technology and advanced bioinformatics analysis, which allows for very precise detection of chromosomal abnormalities.

Scope of research:

• Down syndrome
• Edwards syndrome
• Patau syndrome

The test can detect monosomy X (Turner syndrome). The test also identifies other sex chromosome abnormalities such as Klinefelter syndrome (XXY), Jacobs syndrome (XYY), and XXX syndrome.

The NIFTY test is characterized by high sensitivity and specificity, often exceeding 99% for major trisomies (21, 18, 13). This means a low rate of false positives and false negatives. However, it is a screening test, which means that results indicating high risk require diagnostic confirmation through invasive procedures such as amniocentesis. NIFTY test results are typically available within 6-10 business days of sample collection.

The NIFTY test is widely available around the world and is used by many expectant parents who want accurate information about their baby’s genetic health early in pregnancy.